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PREMISES-DESIGN, CONSTRUCTION, LAYOUT AND MAINTENANCE QUALITY ASSURANCE (QA)

  PREMISES-DESIGN, CONSTRUCTION, LAYOUT AND MAINTENANCE INTRODUCTION In any industry, manufacturing operations must be carried out under clean and hygienic. conditions. However, in the pharmaceutical industry, the condition of the premises assumes critical importance because of the nature of the products being manufactured. Both the external and internal environments must be geared to be conducive to maintain the quality and safety of drug products. Special care must also be taken to prevent contamination of the products and therefore, the location, design, construction and layout of premises is a vital part of the GMP regulations Premises refers to the buildings and facilities where pharmaceutical processing is done. These places must comply with cGMP requirements. LOCATION Premises must be located in a site that is of a size suitable to house all the different departments. The nature of manufacturing and testing to be performed, the magnitude of the operation in t...

Identification of bacteria using staining techniques || Identification of bacteria using staining techniques and biochemical test (IMViC) MICROBIOLOGY

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  IDENTIFICATION OF BACTERIA USING STAINING TECHNIQUES Introduction ·   Staining is technique used in microscopy to enhance contrast in the microscopic image. Stains and dyes are frequently used in biological tissues for viewing, often with the aid of different microscopes. ·    Stains may be used to define and examine bulk tissues (highlighting, for example, muscle fibers or connective tissue), cell populations (classifying different blood cells, for instance), or organelles within individual cells. ·       Bacteria have nearly the same refractive index as water, therefore, when they are observed under a microscope, they are opaque or nearly invisible to the naked eye. ·    Different types of staining methods are used to make the cells and their internal structures more visible under the light microscope. ·      Microscopes are of little use unless the specimens for viewing...